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Sisters Sandwich Shoppe serves up sandwiches with a side of nostalgia in Southampton

Sisters Sandwich Shoppe serves up sandwiches with a side of nostalgia in Southampton

In St. Louis' Southampton neighborhood, the sisters behind an established area café recently opened a new adjacent sandwich shop. Sisters Sandwich Shoppe debuted in April, featuring a menu of hot and cold sandwiches and a retro atmosphere.

The lunchtime concept comes from sisters Tracy Calabro and Jules Karagiannis, who opened the neighboring Espresso Yourself Coffee & Cafe in 2018. When the space next door to the café became available, they saw an opportunity to expand their offerings.

“We’re so grateful to be in such a vibrant neighborhood like Southampton. The support here is just mind-blowing,” says Karagiannis, who previously co-owned The Tenderloin Room with her husband, Dino, before selling it prior to the pandemic. “Ever since the Macklind Deli burned down in 2018, everyone around here has really missed having a sandwich shop. We thought we could fill that need in the neighborhood.”

The 1,200-square-foot space mirrors the size of the connected café, with an entryway between the businesses so customers can come and go between the two. The décor at Sisters takes on a decidedly nostalgic theme, made up of classic Americana pop-culture photos and mementos from the sisters’ personal collections – even an old Blockbuster tape that never quite made it back to the store.

The food menu is primarily made up of nine sandwich options on Bridge Bread Bakery bread, such as the Gabagool, made with roast beef, salami, capicola, provolone, lettuce, tomato, red onion, diced pepperoncini, pickles and Italian vinaigrette on a hoagie, or the signature Sisters Sammie, fried bologna and American cheese topped with Red Hot Riplets on top of white bread. Gluten-free bread is also available to sub in for any sandwich.

“We make classic sandwiches but put the Sisters twist on it," Karagiannis says. "One of the first ones we knew we wanted to do was fried bologna because we grew up on it together. As far as what we decided to call the sandwiches, it was definitely a family affair. All of our children are big sandwich connoisseurs and had a big say in coming up with fun names.”

Options like a lemon orzo soup, a Greek salad and the You Don’t Eat No Meat sandwich also pay homage to the Greek heritage of Karagiannis’ husband and their daughters. The vegetarian sandwich comes with tomato, red onion, yellow pepper, cucumber, romaine, feta, sun-dried tomato spread and balsamic vinaigrette on an everything bagel.

As for snacks, local offerings include potato chips from Billy Goat Chip Company and gluten-free gooey butter cookies from Prioritized Pastries. To drink, choose from options such as canned Vess sodas and WellBeing Brewing Co. CBD sparkling waters.

Sisters Sandwich Shoppe is open Thursday through Sunday from 11am to 3pm.

Sisters Sandwich Shoppe, 5353 Devonshire, Southampton, St. Louis, Missouri, 314.405.8011,

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