Carisa Stark’s restaurant isn’t exactly in the center of a bustling metropolis, so she has to make sure she somehow reaches customers within an 80-mile-plus radius of tiny Perryville, Missouri, south of Ste. Genevieve.

Enticing Instagram photos of Mary Jane Burgers & Brew have helped make the joint a destination restaurant in southeast Missouri; Stark opened Mary Jane in 2013 after a few months with a food truck. “It’s basically a collection of ideas from all my years of traveling,” she says of the burger-heavy menu, which also features street tacos, sandwiches and small plates. “We tried to create a burger menu that is really unique and make sure that it’s like nothing anyone has ever had in this area before.”

Don’t miss Mary Jane’s biggest burger, the John Boy: a double patty topped with apple-smoked bacon, pepper Jack cheese, hand-breaded onion petals and housemade chipotle aïoli. The burger is named after bartender John Sadler, who will serve as head brewer along with Matt Ruesler, executive chef and avid homebrewer, at the brewery Stark is opening a few doors down from Mary Jane’s, Jackson Street Brew Co., later this year.

Mary Jane Burgers & Brew, 102 N. Jackson St., Perryville, Missouri, 573.547.6279, maryjaneburgers.com